United States
Germany
Japan
United Kingdom
China
NPC1L1 (NM_001101648) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC220643L4V
- LentiORF®
-
Lenti ORF particles, NPC1L1 (mGFP-tagged)-Human NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (NPC1L1), transcript variant 2, 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 12,540.00
货期*
详询
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | NPC1L1 (NM_001101648) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | LDLCQ7; NPC11L1; SLC65A2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001101648 |
| ORF Size | 3996 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC220643).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001101648.1, NP_001095118.1 |
| RefSeq Size | 4985 bp |
| RefSeq ORF | 3999 bp |
| Locus ID | 29881 |
| Protein Families | Druggable Genome, Transmembrane |
| MW | 145.76 kDa |
| Gene Summary | The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
