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Repulsive Guidance Molecule C (HFE2) (NM_202004) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC214583L3V
- LentiORF®
-
Lenti ORF particles, HFE2 (Myc-DDK-tagged)-Human hemochromatosis type 2 (juvenile) (HFE2), transcript variant c, 200ul, >10^7 TU/mL
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Specifications
| Product Data | |
| Product Name | Repulsive Guidance Molecule C (HFE2) (NM_202004) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | HFE2; HFE2A; JH; RGMC |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_202004 |
| ORF Size | 600 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC214583).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_202004.2 |
| RefSeq Size | 1438 bp |
| RefSeq ORF | 603 bp |
| Locus ID | 148738 |
| Protein Families | Transmembrane |
| MW | 21.3 kDa |
| Gene Summary | The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015] |
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