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Adducin 2 (ADD2) (NM_017482) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC212102L4V
- LentiORF®
-
Lenti ORF particles, ADD2 (mGFP-tagged) - Human adducin 2 (beta) (ADD2), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 11,305.00
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Specifications
| Product Data | |
| Product Name | Adducin 2 (ADD2) (NM_017482) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ADDB |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_017482 |
| ORF Size | 1680 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC212102).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_017482.1, NP_059516.1 |
| RefSeq Size | 2775 bp |
| RefSeq ORF | 1680 bp |
| Locus ID | 119 |
| Domains | Aldolase_II |
| MW | 62.3 kDa |
| Gene Summary | Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010] |
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