United States
Germany
Japan
United Kingdom
China
SPPL3 (NM_139015) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC210096L2V
- LentiORF®
-
Lenti ORF particles, SPPL3 (mGFP-tagged) - Human signal peptide peptidase 3 (SPPL3), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 9,975.00
货期*
详询
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | SPPL3 (NM_139015) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | IMP2; MDHV1887; PRO4332; PSH1; PSL4 |
| Vector | pLenti-C-mGFP |
| ACCN | NM_139015 |
| ORF Size | 1152 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC210096).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_139015.3 |
| RefSeq Size | 4139 bp |
| RefSeq ORF | 1155 bp |
| Locus ID | 121665 |
| Domains | PSN, DUF435 |
| Protein Families | Protease, Transmembrane |
| MW | 42.3 kDa |
| Gene Summary | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries (PubMed:16873890, PubMed:25354954, PubMed:25827571). Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1 (PubMed:25354954, PubMed:25827571). Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852). May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130 (PubMed:23132852). Plays a role in the regulation of cellular glycosylation processes (PubMed:25354954). Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner (PubMed:25384971).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
