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DUSP8 (NM_004420) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC208337L4V
- LentiORF®
-
Lenti ORF particles, DUSP8 (mGFP-tagged) - Human dual specificity phosphatase 8 (DUSP8), 200ul, >10^7 TU/mL
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CNY 12,160.00
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规格
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Specifications
| Product Data | |
| Product Name | DUSP8 (NM_004420) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | C11orf81; HB5; HVH-5; HVH8 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_004420 |
| ORF Size | 1875 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC208337).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_004420.1 |
| RefSeq Size | 2377 bp |
| RefSeq ORF | 1878 bp |
| Locus ID | 1850 |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | MAPK signaling pathway |
| MW | 65.6 kDa |
| Gene Summary | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008] |
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