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LEFTY2 (NM_003240) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC207799L3V
- LentiORF®
-
Lenti ORF particles, LEFTY2 (Myc-DDK tagged) - Human left-right determination factor 2 (LEFTY2), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
| Product Data | |
| Product Name | LEFTY2 (NM_003240) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | EBAF; LEFTA; LEFTYA; TGFB4 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_003240 |
| ORF Size | 1098 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC207799).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_003240.2 |
| RefSeq Size | 2187 bp |
| RefSeq ORF | 1101 bp |
| Locus ID | 7044 |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | TGF-beta signaling pathway |
| MW | 40.9 kDa |
| Gene Summary | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. This gene is closely linked to both a related family member and a related pseudogene. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016] |
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