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KHDRBS2 (NM_152688) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC205428L3V
- LentiORF®
-
Lenti ORF particles, KHDRBS2 (Myc-DDK tagged) - Human KH domain containing, RNA binding, signal transduction associated 2 (KHDRBS2), 200ul, >10^7 TU/mL
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CNY 8,930.00
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Specifications
| Product Data | |
| Product Name | KHDRBS2 (NM_152688) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | SLM-1; SLM1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_152688 |
| ORF Size | 1047 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC205428).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_152688.1, NP_689901.1 |
| RefSeq Size | 2336 bp |
| RefSeq ORF | 1050 bp |
| Locus ID | 202559 |
| Domains | KH |
| MW | 38.9 kDa |
| Gene Summary | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis.[UniProtKB/Swiss-Prot Function] |
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