TDP1 (NM_001008744) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC201888L3V
- LentiORF®
-
Lenti ORF particles, TDP1 (Myc-DDK tagged) - Human tyrosyl-DNA phosphodiesterase 1 (TDP1), transcript variant 2, 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 8,930.00
Cited in 2 publications. |
Product images
![](https://cdn.origene.com/img/defaults-img.jpg)
CNY 2,950.00
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Product Name | TDP1 (NM_001008744) Human Tagged ORF Clone Lentiviral Particle |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001008744 |
ORF Size | 1824 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC201888).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001008744.1 |
RefSeq Size | 3540 bp |
RefSeq ORF | 1827 bp |
Locus ID | 55775 |
Protein Families | Druggable Genome |
MW | 68.4 kDa |
Gene Summary | The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). [provided by RefSeq, Aug 2016] |
Citations (2)
The use of this cDNA Clones has been cited in the following citations: |
---|
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
,null,
Nature Communications
,PubMed ID 34408146
[TDP1]
|
Analysis of the active site mechanism of Tyrosyl-DNA phosphodiesterase I: a member of the phospholipase D superfamily
,null,
Journal of Molecular Biology
,PubMed ID 22155078
[TDP1]
|
Documents
Product Manuals |
FAQs |
SDS |