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FKBP12 (FKBP1A) (NM_054014) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC200662L3V
- LentiORF®
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Lenti ORF particles, FKBP1A (Myc-DDK tagged) - Human FK506 binding protein 1A, 12kDa (FKBP1A), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 7,410.00
| Cited in 1 publication. |
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CNY 1,999.00
CNY 2,700.00
CNY 2,950.00
Specifications
| Product Data | |
| Product Name | FKBP12 (FKBP1A) (NM_054014) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | FKBP-1A; FKBP-12; FKBP1; FKBP12; PKC12; PKCI2; PPIASE |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_054014 |
| ORF Size | 324 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC200662).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_054014.1 |
| RefSeq Size | 901 bp |
| RefSeq ORF | 327 bp |
| Locus ID | 2280 |
| Domains | FKBP |
| Protein Families | Druggable Genome |
| MW | 12 kDa |
| Gene Summary | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
,null,
Cell Chemical Biology
,PubMed ID 33894161
[FKBP1A]
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