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Cyp1a1 (NM_009992) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR227414L4V
- LentiORF®
-
Lenti ORF particles, Cyp1a1 (GFP-tagged) - Mouse cytochrome P450, family 1, subfamily a, polypeptide 1 (Cyp1a1), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 10,925.00
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Specifications
| Product Data | |
| Product Name | Cyp1a1 (NM_009992) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AHH; AHRR; CP11; Cyp1a2; CYPIA1; P450-1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_009992 |
| ORF Size | 1572 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR227414).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_009992.4, NP_034122.1 |
| RefSeq Size | 2716 bp |
| RefSeq ORF | 1575 bp |
| Locus ID | 13076 |
| Gene Summary | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions. Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation. Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer. May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent).[UniProtKB/Swiss-Prot Function] |
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