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Lepr (NM_001122899) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226858L3V
- LentiORF®
-
Lenti ORF particles, Lepr (Myc-DDK-tagged) - Mouse leptin receptor (Lepr), transcript variant 3, 200ul, >10^7 TU/mL
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CNY 13,965.00
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Specifications
| Product Data | |
| Product Name | Lepr (NM_001122899) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | db; diabetes; Leprb; LEPROT; Modb1; OB-RGRP; obese-like; obl; Obr |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001122899 |
| ORF Size | 2682 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226858).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001122899.1 |
| RefSeq Size | 5571 bp |
| RefSeq ORF | 2685 bp |
| Locus ID | 16847 |
| Gene Summary | Receptor for hormone LEP/leptin (Probable) (PubMed:11861497). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS (PubMed:10799542, PubMed:25383904, PubMed:11923481, PubMed:11861497). In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:10660043, PubMed:12594516). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25383904, PubMed:11923481). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis (PubMed:12594516). Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus (PubMed:25383904). Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T-cells. Leptin increases Th1 and suppresses Th2 cytokine production (PubMed:9732873).[UniProtKB/Swiss-Prot Function] |
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