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Usp33 (NM_133247) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226445L4V
- LentiORF®
-
Lenti ORF particles, Usp33 (GFP-tagged) - Mouse ubiquitin specific peptidase 33 (Usp33), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 15,770.00
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Specifications
| Product Data | |
| Product Name | Usp33 (NM_133247) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 9830169D19Rik; AA409780; Vdu1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_133247 |
| ORF Size | 2727 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226445).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_133247.3, NP_573510.2 |
| RefSeq Size | 4206 bp |
| RefSeq ORF | 2730 bp |
| Locus ID | 170822 |
| Gene Summary | Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.[UniProtKB/Swiss-Prot Function] |
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