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Usp2 (NM_198091) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226435L4V
- LentiORF®
-
Lenti ORF particles, Usp2 (GFP-tagged) - Mouse ubiquitin specific peptidase 2 (Usp2), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 9,405.00
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Specifications
| Product Data | |
| Product Name | Usp2 (NM_198091) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | B930035K21Rik; Ubp41 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_198091 |
| ORF Size | 1188 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226435).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_198091.2, NP_932759.1 |
| RefSeq Size | 3241 bp |
| RefSeq ORF | 1191 bp |
| Locus ID | 53376 |
| Gene Summary | Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (By similarity). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (By similarity). Has no deubiquitinase activity against p53/TP53 (By similarity). Prevents MDM2-mediated degradation of MDM4 (By similarity). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (PubMed:23213472, PubMed:25238854, PubMed:26756164). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (PubMed:25238854).[UniProtKB/Swiss-Prot Function] |
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