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Pik3r1 (NM_001024955) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226192L3V
- LentiORF®
-
Lenti ORF particles, Pik3r1 (Myc-DDK-tagged) - Mouse phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) (Pik3r1), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 9,025.00
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Specifications
| Product Data | |
| Product Name | Pik3r1 (NM_001024955) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | p50alpha; p55alpha; p85alpha; PI3K |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001024955 |
| ORF Size | 1362 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226192).
|
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001024955.1, NP_001020126.1 |
| RefSeq Size | 5843 bp |
| RefSeq ORF | 1365 bp |
| Locus ID | 18708 |
| Gene Summary | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926).[UniProtKB/Swiss-Prot Function] |
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