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Pik3r1 (NM_001077495) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226181L4V
- LentiORF®
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Lenti ORF particles, Pik3r1 (GFP-tagged) - Mouse phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) (Pik3r1), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 13,395.00
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Specifications
| Product Data | |
| Product Name | Pik3r1 (NM_001077495) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | p50alpha; p55alpha; p85alpha; PI3K |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001077495 |
| ORF Size | 2172 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226181).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001077495.2, NP_001070963.1 |
| RefSeq Size | 6928 bp |
| RefSeq ORF | 2175 bp |
| Locus ID | 18708 |
| Gene Summary | Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926).[UniProtKB/Swiss-Prot Function] |
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