United States
Germany
Japan
United Kingdom
China
Epha2 (NM_010139) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226151L4V
- LentiORF®
-
Lenti ORF particles, Epha2 (GFP-tagged) - Mouse Eph receptor A2 (Epha2), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 16,530.00
货期*
详询
规格
Product images
经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Epha2 (NM_010139) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AW545284; Eck; Myk2; Sek-2; Sek2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_010139 |
| ORF Size | 2931 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226151).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_010139.3, NP_034269.2 |
| RefSeq Size | 3948 bp |
| RefSeq ORF | 2934 bp |
| Locus ID | 13836 |
| Gene Summary | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells (PubMed:29749928). Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
