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Fzd5 (NM_022721) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR226069L3V
- LentiORF®
-
Lenti ORF particles, Fzd5 (Myc-DDK-tagged) - Mouse frizzled homolog 5 (Drosophila) (Fzd5), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 10,450.00
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Specifications
| Product Data | |
| Product Name | Fzd5 (NM_022721) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 5330434N09Rik; AI427138; Fz-5; Fz5; mFz5 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_022721 |
| ORF Size | 1758 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR226069).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_022721.3, NP_073558.2 |
| RefSeq Size | 6930 bp |
| RefSeq ORF | 1758 bp |
| Locus ID | 14367 |
| Gene Summary | Receptor for Wnt proteins (PubMed:11092808, PubMed:18230341). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (PubMed:11092808). In neurons, activation of WNT7A promotes formation of synapses (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:18230341). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (PubMed:11092808).[UniProtKB/Swiss-Prot Function] |
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