United States
Germany
Japan
United Kingdom
China
Shc1 (NM_001113331) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR225873L3V
- LentiORF®
-
Lenti ORF particles, Shc1 (Myc-DDK-tagged) - Mouse src homology 2 domain-containing transforming protein C1 (Shc1), transcript variant 1, 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 10,450.00
货期*
详询
规格
Product images
经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Shc1 (NM_001113331) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | p66; p66shc; Shc; ShcA |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001113331 |
| ORF Size | 1737 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR225873).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001113331.2, NP_001106802.1 |
| RefSeq Size | 3569 bp |
| RefSeq ORF | 1740 bp |
| Locus ID | 20416 |
| Gene Summary | Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p47Shc and isoform p52 may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
