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Socs3 (NM_007707) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR225636L4V
- LentiORF®
-
Lenti ORF particles, Socs3 (GFP-tagged) - Mouse suppressor of cytokine signaling 3 (Socs3), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Socs3 (NM_007707) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Cis3; Cish3; EF-10; Ef10; SSI-3; Ssi3 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_007707 |
| ORF Size | 675 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR225636).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_007707.3, NP_031733.1 |
| RefSeq Size | 2742 bp |
| RefSeq ORF | 678 bp |
| Locus ID | 12702 |
| Gene Summary | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to recognize IL6ST.[UniProtKB/Swiss-Prot Function] |
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