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Rbl1 (NM_001139516) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR225589L3V
- LentiORF®
-
Lenti ORF particles, Rbl1 (Myc-DDK-tagged) - Mouse retinoblastoma-like 1 (p107) (Rbl1), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 10,545.00
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Specifications
| Product Data | |
| Product Name | Rbl1 (NM_001139516) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AW547426; p107; PRB1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001139516 |
| ORF Size | 1782 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR225589).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001139516.1, NP_001132988.1 |
| RefSeq Size | 2400 bp |
| RefSeq ORF | 1785 bp |
| Locus ID | 19650 |
| Gene Summary | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.[UniProtKB/Swiss-Prot Function] |
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