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Il1f6 (NM_019450) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR225118L3V
- LentiORF®
-
Lenti ORF particles, Il1f6 (Myc-DDK-tagged) - Mouse interleukin 1 family, member 6 (Il1f6), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Il1f6 (NM_019450) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Fil1; IL-1H1; Il1f9; IL1RP2; Il36a |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_019450 |
| ORF Size | 480 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR225118).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_019450.3, NP_062323.1 |
| RefSeq Size | 883 bp |
| RefSeq ORF | 483 bp |
| Locus ID | 54448 |
| Gene Summary | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Induces the production of proinflammatory cytokines, including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23 in bone marrow-derived dendritic cells (BMDCs). Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. May play a role in proinflammatory effects in the lung: induces the expression of CXCL1 and CXCL2 in the lung, and the expression of TNF-alpha, IL-36c, IL-1A, IL-1B, CXCL1 and CXCL2 in isolated splenic CD11c(+) alveolar macrophages. May be involved in T-cell maturation by stimulating the surface expression of CD40 and modestly CD80 and CD86 in splenic CD11c(+) cells. May be involved in CD4(+) T-cell proliferation. Induces NF-kappa B activation in macrophages.[UniProtKB/Swiss-Prot Function] |
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