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Asah2 (NM_018830) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR224900L3V
- LentiORF®
-
Lenti ORF particles, Asah2 (Myc-DDK-tagged) - Mouse N-acylsphingosine amidohydrolase 2 (Asah2), 200ul, >10^7 TU/mL
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CNY 12,445.00
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Specifications
| Product Data | |
| Product Name | Asah2 (NM_018830) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI585898 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_018830 |
| ORF Size | 2268 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR224900).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_018830.1, NP_061300.1 |
| RefSeq Size | 4835 bp |
| RefSeq ORF | 2271 bp |
| Locus ID | 54447 |
| Gene Summary | Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10753931, PubMed:10652340, PubMed:16380386). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:14557071). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:10652340, PubMed:21613224). Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16126722). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (PubMed:16126722). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (PubMed:16380386).[UniProtKB/Swiss-Prot Function] |
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