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Rgma (NM_177740) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR224639L4V
- LentiORF®
-
Lenti ORF particles, Rgma (GFP-tagged) - Mouse RGM domain family, member A (Rgma), 200ul, >10^7 TU/mL
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CNY 10,070.00
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Specifications
| Product Data | |
| Product Name | Rgma (NM_177740) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | BC059072; C230063O06 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_177740 |
| ORF Size | 1362 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR224639).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_177740.5, NP_808408.2 |
| RefSeq Size | 3586 bp |
| RefSeq ORF | 1365 bp |
| Locus ID | 244058 |
| Gene Summary | Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.[UniProtKB/Swiss-Prot Function] |
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