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Ifi35 (NM_027320) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR223920L4V
- LentiORF®
-
Lenti ORF particles, Ifi35 (GFP-tagged) - Mouse interferon-induced protein 35 (Ifi35), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Ifi35 (NM_027320) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2010008K16Rik; AW986054; ifi-35; IFP35 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_027320 |
| ORF Size | 861 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR223920).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_027320.4, NP_081596.1 |
| RefSeq Size | 1360 bp |
| RefSeq ORF | 861 bp |
| Locus ID | 70110 |
| Gene Summary | Acts as a signaling pathway regulator involved in innate immune system response (PubMed:29350881). In response to interferon IFN-alpha, associates in a complex with transcriptional regulator NMI to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 and correlates with IFI35 dephosphorylation (By similarity). In complex with NMI, inhibits virus-triggered type I interferon/IFN-beta production (By similarity). In complex with NMI, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of the NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (PubMed:29350881). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation when actively released by macrophage to the extracellular space during cell injury and pathogen invasion (By similarity). Macrophage-secreted IFI35 activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines (By similarity).[UniProtKB/Swiss-Prot Function] |
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