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Nmnat1 (NM_133435) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR222867L4V
- LentiORF®
-
Lenti ORF particles, Nmnat1 (GFP-tagged) - Mouse nicotinamide nucleotide adenylyltransferase 1 (Nmnat1), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Nmnat1 (NM_133435) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2610529L11Rik; 5730441G13Rik; D4Cole1e; nmnat |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_133435 |
| ORF Size | 858 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR222867).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_133435.1 |
| RefSeq Size | 954 bp |
| RefSeq ORF | 858 bp |
| Locus ID | 66454 |
| Gene Summary | Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:15381699). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (By similarity). Can use triazofurin monophosphate (TrMP) as substrate (By similarity). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (By similarity). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (By similarity). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Protects against axonal degeneration following mechanical or toxic insults (PubMed:15310905, PubMed:16914673). Delays axonal degeneration after axotomy. Results in a >10-fold increase in intact neurites 72 hours after injury (PubMed:16914673).[UniProtKB/Swiss-Prot Function] |
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