Dyrk1a (NM_007890) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR221655L4V
- LentiORF®
Lenti ORF particles, Dyrk1a (GFP-tagged) - Mouse dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 13,965.00
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Specifications
Product Data | |
Product Name | Dyrk1a (NM_007890) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | 2310043O08Rik; D16Ertd272e; D16Ertd493e; Dyrk; ENSMUSG00000074897; Gm10783; mmb; Mnbh; Mp86 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_007890 |
ORF Size | 2289 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR221655).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_007890.2, NP_031916.1 |
RefSeq Size | 6035 bp |
RefSeq ORF | 2292 bp |
Locus ID | 13548 |
Gene Summary | Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (PubMed:20167603).[UniProtKB/Swiss-Prot Function] |
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