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Fer (NM_001037997) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR220921L4V
- LentiORF®
-
Lenti ORF particles, Fert2 (GFP-tagged) - Mouse fer (fms/fps related) protein kinase, testis specific 2 (Fert2), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 14,725.00
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Specifications
| Product Data | |
| Product Name | Fer (NM_001037997) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AV082135; C330004K01Rik; Fert; Fert2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001037997 |
| ORF Size | 2469 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR220921).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001037997.2, NP_001033086.2 |
| RefSeq Size | 3026 bp |
| RefSeq ORF | 2472 bp |
| Locus ID | 14158 |
| Gene Summary | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3 according to PubMed:10878010 and PubMed:19159681, but clearly plays a redundant role in STAT3 phosphorylation. According to PubMed:11134346, cells where wild type FER has been replaced by a kinase-dead mutant show no reduction in STAT3 phosphorylation. Phosphorylates TMF1. Isoform 3 lacks kinase activity.[UniProtKB/Swiss-Prot Function] |
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