Scin (NM_009132) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR218765L4V
- LentiORF®
Lenti ORF particles, Scin (GFP-tagged) - Mouse scinderin (Scin), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 12,065.00
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Specifications
Product Data | |
Product Name | Scin (NM_009132) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | adseverin; AW545522 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_009132 |
ORF Size | 1845 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR218765).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_009132.2, NP_033158.2 |
RefSeq Size | 2708 bp |
RefSeq ORF | 1848 bp |
Locus ID | 20259 |
Gene Summary | Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:9671468). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+) (PubMed:9671468). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (PubMed:25275604, PubMed:25681458). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (By similarity).[UniProtKB/Swiss-Prot Function] |
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