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Scap (NM_001103162) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR218374L4V
- LentiORF®
-
Lenti ORF particles, Scap (GFP-tagged) - Mouse SREBF chaperone (Scap), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 20,330.00
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Specifications
| Product Data | |
| Product Name | Scap (NM_001103162) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 9530044G19; mKIAA0199 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001103162 |
| ORF Size | 3828 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR218374).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001103162.1 |
| RefSeq Size | 4154 bp |
| RefSeq ORF | 3831 bp |
| Locus ID | 235623 |
| Gene Summary | Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway.[UniProtKB/Swiss-Prot Function] |
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