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Cdk8 (NM_153599) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR218219L3V
- LentiORF®
-
Lenti ORF particles, Cdk8 (Myc-DDK-tagged) - Mouse cyclin-dependent kinase 8 (Cdk8), 200ul, >10^7 TU/mL
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CNY 9,120.00
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Specifications
| Product Data | |
| Product Name | Cdk8 (NM_153599) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | MGC37111 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_153599 |
| ORF Size | 1392 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR218219).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_153599.3 |
| RefSeq Size | 2586 bp |
| RefSeq ORF | 1395 bp |
| Locus ID | 264064 |
| Gene Summary | Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).[UniProtKB/Swiss-Prot Function] |
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