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Pold1 (NM_011131) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR217545L3V
- LentiORF®
-
Lenti ORF particles, Pold1 (Myc-DDK-tagged) - Mouse polymerase (DNA directed), delta 1, catalytic subunit (Pold1), 200ul, >10^7 TU/mL
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CNY 16,435.00
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Specifications
| Product Data | |
| Product Name | Pold1 (NM_011131) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 125kDa |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_011131 |
| ORF Size | 3318 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR217545).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011131.3 |
| RefSeq Size | 3428 bp |
| RefSeq ORF | 3318 bp |
| Locus ID | 18971 |
| Gene Summary | As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites.[UniProtKB/Swiss-Prot Function] |
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