Fbxo6 (NM_001163705) Mouse Tagged ORF Clone Lentiviral Particle

CAT#: MR216991L4V

  • LentiORF®

Lenti ORF particles, Fbxo6 (GFP-tagged) - Mouse F-box protein 6 (Fbxo6), transcript variant 3, 200ul, >10^7 TU/mL

ORF Plasmid: DDK tGFP



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CNY 8,360.00


货期*
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规格
    • 200 ul

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Specifications

Product Data
Product Name Fbxo6 (NM_001163705) Mouse Tagged ORF Clone Lentiviral Particle
Synonyms AA408845; FBG2; Fbs2; Fbx6b; Fbxo6b
Vector pLenti-C-mGFP-P2A-Puro
ACCN NM_001163705
ORF Size 888 bp
Sequence Data
The ORF insert of this clone is exactly the same as(MR216991).
OTI Disclaimer The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Reference Data
RefSeq NM_001163705.1, NP_001157177.1
RefSeq Size 1213 bp
RefSeq ORF 888 bp
Locus ID 50762
Gene Summary Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans.[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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