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Smarca5 (NM_053124) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211537L4V
- LentiORF®
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Lenti ORF particles, Smarca5 (GFP-tagged) - Mouse SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (Smarca5), 200ul, >10^7 TU/mL
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CNY 17,480.00
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Specifications
| Product Data | |
| Product Name | Smarca5 (NM_053124) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 4933427E24Rik; D030040M08Rik; D330027N15Rik; MommeD4; Snf2h |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_053124 |
| ORF Size | 3153 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211537).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_053124.2, NP_444354.2 |
| RefSeq Size | 4658 bp |
| RefSeq ORF | 3156 bp |
| Locus ID | 93762 |
| Gene Summary | Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.[UniProtKB/Swiss-Prot Function] |
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