United States
Germany
Japan
United Kingdom
China
Usp28 (NM_175482) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211535L3V
- LentiORF®
-
Lenti ORF particles, Usp28 (Myc-DDK-tagged) - Mouse ubiquitin specific peptidase 28 (Usp28), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 15,770.00
货期*
详询
规格
Product images
经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Usp28 (NM_175482) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 9830148O20Rik; AU022237; mKIAA1515 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_175482 |
| ORF Size | 3153 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211535).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_175482.3, NP_780691.2 |
| RefSeq Size | 4220 bp |
| RefSeq ORF | 3156 bp |
| Locus ID | 235323 |
| Gene Summary | Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBXW7) complex. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
