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Kpnb1 (NM_008379) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211042L3V
- LentiORF®
-
Lenti ORF particles, Kpnb1 (Myc-DDK-tagged) - Mouse karyopherin (importin) beta 1 (Kpnb1), 200ul, >10^7 TU/mL
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CNY 13,775.00
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Specifications
| Product Data | |
| Product Name | Kpnb1 (NM_008379) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AA409963; Impnb; IPOB |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_008379 |
| ORF Size | 2628 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211042).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008379.3, NP_032405.3 |
| RefSeq Size | 5909 bp |
| RefSeq ORF | 2631 bp |
| Locus ID | 16211 |
| Gene Summary | Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Imports SNAI1 and PRKCI into the nucleus (By similarity).[UniProtKB/Swiss-Prot Function] |
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