Ercc3 (NM_133658) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR210632L3V
- LentiORF®
Lenti ORF particles, Ercc3 (Myc-DDK-tagged) - Mouse excision repair cross-complementing rodent repair deficiency, complementation group 3 (Ercc3), 200ul, >10^7 TU/mL
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CNY 12,730.00
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Specifications
Product Data | |
Product Name | Ercc3 (NM_133658) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | BTF2 p89; Ercc-3; XPB |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_133658 |
ORF Size | 2352 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR210632).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_133658.1 |
RefSeq Size | 2673 bp |
RefSeq ORF | 2352 bp |
Locus ID | 13872 |
Gene Summary | ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.[UniProtKB/Swiss-Prot Function] |
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