United States
Germany
Japan
United Kingdom
China
Fzd6 (NM_001162494) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210188L4V
- LentiORF®
-
Lenti ORF particles, Fzd6 (GFP-tagged) - Mouse frizzled homolog 6 (Drosophila) (Fzd6), transcript variant 2, 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 13,205.00
货期*
详询
规格
Product images
经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Fzd6 (NM_001162494) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Fz6 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001162494 |
| ORF Size | 2127 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210188).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001162494.1, NP_001155966.1 |
| RefSeq Size | 4086 bp |
| RefSeq ORF | 2130 bp |
| Locus ID | 14368 |
| Gene Summary | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (By similarity). Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
