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Leo1 (NM_001039522) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209896L3V
- LentiORF®
-
Lenti ORF particles, Leo1 (Myc-DDK-tagged) - Mouse Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) (Leo1), 200ul, >10^7 TU/mL
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CNY 11,400.00
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规格
| Cited in 1 publication. |
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经常一起买 (3)
Specifications
| Product Data | |
| Product Name | Leo1 (NM_001039522) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Gm185 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001039522 |
| ORF Size | 2004 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209896).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001039522.1, NP_001034611.1 |
| RefSeq Size | 2192 bp |
| RefSeq ORF | 2004 bp |
| Locus ID | 235497 |
| Gene Summary | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity).[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia
,null,
Oncotarget
,PubMed ID 29774127
[Leo1]
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