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Pias1 (NM_019663) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209770L3V
- LentiORF®
-
Lenti ORF particles, Pias1 (Myc-DDK-tagged) - Mouse protein inhibitor of activated STAT 1 (Pias1), 200ul, >10^7 TU/mL
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CNY 11,210.00
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规格
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Specifications
| Product Data | |
| Product Name | Pias1 (NM_019663) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2900068C24Rik; Ddxbp1; GBP |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_019663 |
| ORF Size | 1953 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209770).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_019663.2 |
| RefSeq Size | 3856 bp |
| RefSeq ORF | 1956 bp |
| Locus ID | 56469 |
| Gene Summary | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA (By similarity). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB (PubMed:24061474).[UniProtKB/Swiss-Prot Function] |
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