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Tgfbr2 (BC052629) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR209231L2V
- LentiORF®
-
Lenti ORF particles, Tgfbr2 (GFP-tagged) - Mouse transforming growth factor, beta receptor II (cDNA clone MGC:54755 IMAGE:6310023), 200ul, >10^7 TU/mL
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CNY 11,115.00
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Specifications
| Product Data | |
| Product Name | Tgfbr2 (BC052629) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | DNIIR, RIIDN, TbetaRII, TbetaR-II |
| Vector | pLenti-C-mGFP |
| ACCN | BC052629 |
| ORF Size | 1776 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR209231).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC052629 |
| RefSeq Size | 8165 bp |
| RefSeq ORF | 1778 bp |
| Locus ID | 21813 |
| Gene Summary | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).[UniProtKB/Swiss-Prot Function] |
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