Parp2 (NM_009632) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR208862L4V
- LentiORF®
Lenti ORF particles, Parp2 (GFP-tagged) - Mouse poly (ADP-ribose) polymerase family, member 2 (Parp2), 200ul, >10^7 TU/mL
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CNY 11,305.00
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Specifications
Product Data | |
Product Name | Parp2 (NM_009632) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | Adprt2; Adprtl2; ARTD2; Aspartl2; C78626; PARP-2 |
Vector | pLenti-C-mGFP-P2A-Puro |
ACCN | NM_009632 |
ORF Size | 1677 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR208862).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_009632.2 |
RefSeq Size | 1834 bp |
RefSeq ORF | 1680 bp |
Locus ID | 11546 |
Gene Summary | Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair (PubMed:10364231). Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (By similarity). ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Also mediates serine ADP-ribosylation of target proteins following interaction with HPF1; HPF1 conferring serine specificity (By similarity). In addition to proteins, also able to ADP-ribosylate DNA: preferentially acts on 5'-terminal phosphates at DNA strand breaks termini in nicked duplex (By similarity).[UniProtKB/Swiss-Prot Function] |
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