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Traf2 (NM_009422) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208047L4V
- LentiORF®
-
Lenti ORF particles, Traf2 (GFP-tagged) - Mouse TNF receptor-associated factor 2 (Traf2), 200ul, >10^7 TU/mL
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CNY 10,640.00
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Specifications
| Product Data | |
| Product Name | Traf2 (NM_009422) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AI325259 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_009422 |
| ORF Size | 1506 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208047).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_009422.2, NP_033448.2 |
| RefSeq Size | 3044 bp |
| RefSeq ORF | 1506 bp |
| Locus ID | 22030 |
| Gene Summary | Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.[UniProtKB/Swiss-Prot Function] |
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