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Nampt (NM_021524) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR207867L3V
- LentiORF®
-
Lenti ORF particles, Nampt (Myc-DDK-tagged) - Mouse nicotinamide phosphoribosyltransferase (Nampt), 200ul, >10^7 TU/mL
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CNY 9,405.00
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Specifications
| Product Data | |
| Product Name | Nampt (NM_021524) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1110035O14Rik; AI314458; AI480535; NAmPRTase; Pbef; Pbef1; Visfatin |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_021524 |
| ORF Size | 1476 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR207867).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_021524.1, NP_067499.1 |
| RefSeq Size | 4547 bp |
| RefSeq ORF | 1476 bp |
| Locus ID | 59027 |
| Gene Summary | The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.[UniProtKB/Swiss-Prot Function] |
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