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Kremen1 (NM_032396) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR207561L3V
- LentiORF®
-
Lenti ORF particles, Kremen1 (Myc-DDK-tagged) - Mouse kringle containing transmembrane protein 1 (Kremen1), 200ul, >10^7 TU/mL
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CNY 9,215.00
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Specifications
| Product Data | |
| Product Name | Kremen1 (NM_032396) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AV002070; Kremen; Krm1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_032396 |
| ORF Size | 1419 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR207561).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_032396.3, NP_115772.2 |
| RefSeq Size | 4943 bp |
| RefSeq ORF | 1422 bp |
| Locus ID | 84035 |
| Gene Summary | Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity). Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1 (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification (PubMed:27550540).[UniProtKB/Swiss-Prot Function] |
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