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Terf2 (NM_001083118) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR207518L4V
- LentiORF®
-
Lenti ORF particles, Terf2 (GFP-tagged) - Mouse telomeric repeat binding factor 2 (Terf2), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 10,260.00
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Specifications
| Product Data | |
| Product Name | Terf2 (NM_001083118) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | TRF2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_001083118 |
| ORF Size | 1410 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR207518).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001083118.2, NP_001076587.1 |
| RefSeq Size | 2477 bp |
| RefSeq ORF | 1413 bp |
| Locus ID | 21750 |
| Gene Summary | Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology-directed repair (HDR), which can affect telomere length.[UniProtKB/Swiss-Prot Function] |
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