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Stk24 (NM_145465) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206874L4V
- LentiORF®
-
Lenti ORF particles, Stk24 (GFP-tagged) - Mouse serine/threonine kinase 24 (STE20 homolog, yeast) (Stk24), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Stk24 (NM_145465) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1810013H02Rik; C76483; MST-3; Mst3; STE20 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_145465 |
| ORF Size | 1296 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206874).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_145465.2, NP_663440.1 |
| RefSeq Size | 2575 bp |
| RefSeq ORF | 1296 bp |
| Locus ID | 223255 |
| Gene Summary | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. Acts as a key regulator of axon regeneration in the optic nerve and radial nerve (By similarity).[UniProtKB/Swiss-Prot Function] |
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