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Peli1 (NM_023324) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206617L3V
- LentiORF®
-
Lenti ORF particles, Peli1 (Myc-DDK-tagged) - Mouse pellino 1 (Peli1), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Peli1 (NM_023324) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2810468L03Rik; A930031K15Rik; AA409794; AI586297; D11Ertd676e |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_023324 |
| ORF Size | 1257 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206617).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_023324.2, NP_075813.2 |
| RefSeq Size | 3501 bp |
| RefSeq ORF | 1257 bp |
| Locus ID | 67245 |
| Gene Summary | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:16951688). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (By similarity).[UniProtKB/Swiss-Prot Function] |
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