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Pdk4 (NM_013743) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206475L3V
- LentiORF®
-
Lenti ORF particles, Pdk4 (Myc-DDK-tagged) - Mouse pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4), nuclear gene encoding mitochondrial protein, 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Pdk4 (NM_013743) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AV005916 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_013743 |
| ORF Size | 1236 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206475).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_013743.2, NP_038771.1 |
| RefSeq Size | 3453 bp |
| RefSeq ORF | 1239 bp |
| Locus ID | 27273 |
| Gene Summary | Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.[UniProtKB/Swiss-Prot Function] |
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