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Snx6 (NM_026998) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR206384L4V
- LentiORF®
-
Lenti ORF particles, Snx6 (GFP-tagged) - Mouse sorting nexin 6 (Snx6), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Snx6 (NM_026998) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2010006G21Rik; 2610032J07Rik; 2810425K19Rik; AU018928; C85963 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_026998 |
| ORF Size | 1218 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR206384).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_026998.2, NP_081274.2 |
| RefSeq Size | 1880 bp |
| RefSeq ORF | 1221 bp |
| Locus ID | 72183 |
| Gene Summary | Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity (By similarity). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation (By similarity). In association with GIT1 involved in EGFR degradation (PubMed:18523162). Promotes lysosomal degradation of CDKN1B (PubMed:20228253). May contribute to transcription regulation (By similarity).[UniProtKB/Swiss-Prot Function] |
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