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Kmt5a (NM_030241) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR205297L3V
- LentiORF®
-
Lenti ORF particles, Setd8 (Myc-DDK-tagged) - Mouse SET domain containing (lysine methyltransferase) 8 (Setd8), 200ul, >10^7 TU/mL
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CNY 7,410.00
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Specifications
| Product Data | |
| Product Name | Kmt5a (NM_030241) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2410195B05Rik; AA617402; AW536475; PR-SET7; PR/SET07; Setd8 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_030241 |
| ORF Size | 1050 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR205297).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_030241.3, NP_084517.2 |
| RefSeq Size | 2742 bp |
| RefSeq ORF | 1053 bp |
| Locus ID | 67956 |
| Gene Summary | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration (By similarity).[UniProtKB/Swiss-Prot Function] |
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